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KMID : 0624620220550050226
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BMB Reports
2022 Volume.55 No. 5 p.226 ~ p.231
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Endoplasmin regulates differentiation of tonsil-derived mesenchymal stem cells into chondrocytes through ERK signaling
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Kim Hye-Ryeong
Choi Hyeong-Rok
Park Soon-Yong
Song Young-Chul
Kim Jae-Ho
Shim Sang-In
Jun Woo-Jin
Kim Kyung-Jin
Han Jin
Chi Seung-Wook
Leem Sun-Hee
Chung Jin-Woong
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Abstract
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It is well-known that some species of lizard have an exceptional ability known as caudal autotomy (voluntary self-amputation of the tail) as an anti-predation mechanism. After amputation occurs, they can regenerate their new tails in a few days. The new tail section is generally shorter than the original one and is composed of cartilage rather than vertebrae bone. In addition, the skin of the regenerated tail distinctly differs from its original appearance. We performed a proteomics analysis for extracts derived from regenerating lizard tail tissues after amputation and found that endoplasmin (ENPL) was the main factor among proteins up-regulated in expression during regeneration. Thus, we performed further experiments to determine whether ENPL could induce chondrogenesis of tonsil-derived mesenchymal stem cells (T-MSCs). In this study, we found that chondrogenic differentiation was associated with an increase of ENPL expression by ER stress. We also found that ENPL was involved in chondrogenic differentiation of T-MSCs by suppressing extracellular signal-regulated kinase (ERK) phosphorylation.
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KEYWORD
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Chondrocytes, Differentiation, Endoplasmin, Lizard tail extracts (LTEs), Tonsil-derived mesenchymal stem cells (T-MSCs)
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